Corrections: Evolutionary Changes in Influenza B are not Primarily Governed by Antibody Selection

Evolutionary changes in influenza B are not primarily governed by antibody selection.

Influenza B viruses evolve more slowly than human influenza A, but no reasons for the difference have been established. We have analyzed sequence changes in the hemagglutinin and neuraminidase of influenza B viruses (and have determined four hemagglutinin sequences, of B/Bonn/43, B/USSR/100/83, B/Victoria/3/85, and B/Memphis/6/86) in relation to antigenic properties and compared these with simi...

Adjuvantation of Pulmonary-Administered Influenza Vaccine with GPI-0100 Primarily Stimulates Antibody Production and Memory B Cell Proliferation

Adjuvants are key components in vaccines, they help in reducing the required antigen dose but also modulate the phenotype of the induced immune response. We previously showed that GPI-0100, a saponin-derived adjuvant, enhances antigen-specific mucosal and systemic antibody responses to influenza subunit and whole inactivated influenza virus (WIV) vaccine administered via the pulmonary route. Ho...

Evolutionary changes in avian influenza H5N1 viruses in Thailand.

Tropospheric ozone variations governed by changes in stratospheric circulation

Thedownward transport of stratospheric ozone is an important natural source of tropospheric ozone, particularly in the upper troposphere, where changes in ozone have their largest radiative e ect1. Stratospheric circulation is projected to intensify over the coming century, which could lead to an increase in the flux of ozone from the stratosphere to the troposphere2–4. However, large uncertain...

B cell homeostasis and follicle confines are governed by fibroblastic reticular

Fibroblastic reticular cells (FRCs) are known to inhabit T cell-rich areas of lymphoid organs where they function to coordinate T cell and dendritic cell interactions. However, in vivo manipulation of FRCs has been limited by a dearth of genetic tools targeting this lineage. Here, using a mouse model to conditionally ablate FRCs, we demonstrate their indispensable role in anti-viral T cell resp...